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Product Information:

BGB16673

BGB- 16673 is a heterobifunctional small molecule that binds to BTK and E3 ligase, resulting in BTK degradation via ubiquitination.

Cat. No.: EX-A8316    Purity: >98%
Chemical
Chemical structure of BGB16673


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg950In-stock
250mg1600In-stock
500mg2950In-stock
1gget quote


SynonymsBGB-16673
CAS No.2736508-65-7
Purity>98%
FormulaC47H54N12O4
Mol Weight851.0097
Statesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. First Results from a Phase 1, First-in-Human Study of the Bruton's Tyrosine Kinase (BTK) Degrader Bgb-16673 in Patients (Pts) with Relapsed or Refractory (R/R) B-Cell Malignancies (BGB-16673-101). DOI: 10.1182/blood-2023-180109
CoACoA of BGB16673
Smiles:CC=1C=C(C2=C3C(NC(=C3)C4=CC=C(C=N4)N5CCN(CC6CCN(CC6)C7=CC=C(C=C7)N8C(=O)NC(=O)CC8)CC5)=NC=N2)C=CC1[C@H](NC(=O)C9=NC(C(C)(C)C)=NO9)C

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