BGB-8035

BGB-8035 is an orally active, highly selective bruton's tyrosine kinase (BTK) inhibitor with IC50s of 1.1 nM, 99 nM, 621 nM for BTK, TEC, EGFR, respectively. BGB-8035 has antitumor and anti-arthritis activity


Cat. No.: EX-A8567	Purity: >98%

	Chemical structure of BGB-8035

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	530	in_stock
100mg	945	in_stock
250mg	1750	in_stock
500mg	2853	in_stock
1g	5300	in_stock
5g	20686	in_stock

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CAS No.	2283349-24-4
Purity	>98%
Formula	C24H31N5O4
Mol Weight	453.534
Color	White to off-white
State	solid powder
Solubility	DMSO : 50 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years ; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Yunhang Guo, et al. Discovery of BGB-8035, a Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase for B-Cell Malignancies and Autoimmune Diseases. J Med Chem. 2023 Mar 23;66(6):4025-4044.
CoA	CoA of BGB-8035

Smiles:	NC(C1=C2N(N=C1C3=CC(OC)=C(C(OC)=C3)C)[C@H](C4CCN(CC4)C(C=C)=O)CCN2)=O


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