BETA-Lapachone

Beta-Lapachone (β-Lapachone, ARQ-501) is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase.


Cat. No.: EX-A3011	Purity: >98%

	Chemical structure of BETA-Lapachone

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
500mg	660	In-stock
1g	965	In-stock
2g	1560	In-stock
5g	2985	In-stock
10g	5560	In-stock

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CAS No.	4707-32-8
Purity	>98%
Formula	C15H14O3
Mol Weight	242.2699
Color	red
State	solid
Solubility	DMSO : 24 mg/mL (102.28 mM; Need ultrasonic) Ethanol : 8.26 mg/mL (35.43 mM; Need ultrasonic)
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Li, C J et al. “beta-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin.” The Journal of biological chemistry vol. 268,30 (1993): 22463-8. [1]. Planchon, S M et al. “Beta-lapachone-mediated apoptosis in human promyelocytic leukemia (HL-60) and human prostate cancer cells: a p53-independent response.” Cancer research vol. 55,17 (1995): 3706-11. [1]. Kung, Hsiu-Ni et al. “In vitro and in vivo wound healing-promoting activities of beta-lapachone.” American journal of physiology. Cell physiology vol. 295,4 (2008): C931-43. [1]. Flick, Hollie E et al. “The Tumor-Selective Cytotoxic Agent β-Lapachone is a Potent Inhibitor of IDO1.” International journal of tryptophan research : IJTR vol. 6 35-45. 19 Aug. 2013
CoA	CoA of BETA-Lapachone

Smiles:	CC1(C)CCC2=C(O1)C1=C(C=CC=C1)C(=O)C2=O


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