BET bromodomain inhibitor 1

BET bromodomain inhibitor 1 is an orally active, selective bromodomain and extra-terminal (BET) bromodomain inhibitor with an IC50 of 2.6 nM for BRD4. BET bromodomain inhibitor 1 binds to BRD2(2), BRD3(2), BRD4(1), BRD4(2), and BRDT(2) with high affinities (Kd values of 1.3 nM, 1.0 nM, 3.0 nM, 1.6 nM, 2.1 nM, respectively).


Cat. No.: EX-A7611	Purity: >98%

	Chemical structure of BET bromodomain inhibitor 1

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
10mg	500	Inquire
25mg	785	Inquire
50mg	1185	Inquire
100mg	1885	In-stock

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CAS No.	2411226-02-1
Purity	>98%
Formula	C22H19F2N3O4S
Mol Weight	459.466
Color	White to off-white
State	solid powder
Solubility	DMSO : 100 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Zizhou Li, et al. Discovery of 8-Methyl-pyrrolo[1,2- a]pyrazin-1(2 H)-one Derivatives as Highly Potent and Selective Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitors. J Med Chem. 2020 Apr 23;63(8):3956-3975.
CoA	CoA of BET bromodomain inhibitor 1


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