BE2012

BE2012, SR8278 (HY-14415) derivative, is a potent and selective REV-ERBα/β Antagonist with EC50 values of 0.285 and 0.346 μM. BE2012 binds to the ligand-binding domain (LBD) of REV-ERB, preventing the receptor from recruiting co-inhibitory factors and thereby releasing the transcriptional repression on downstream target genes. BE2012 can upregulate the expression of myogenic transcription factors Myf5 and Myod, promoting muscle regeneration and repair in acute muscle injury micemodels .


Cat. No.: EX-A16435	Purity: >98%

	Chemical structure of BE2012

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
25mg	get quote

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


CAS No.	667889-47-6
Purity	>98%
Formula	C18H19N3O
Mol Weight	293.363
Color	White to light yellow
State	Solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃, stored under nitrogen; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Maram L, et al. Discovery of BE2012, a First-in-Class REV-ERBα/β Antagonist with Favorable Selectivity and Pharmacokinetics, and In Vivo Efficacy in Inducing Key Myogenic Factors for Muscle Repair upon Acute Muscle Injury. J Med Chem. 2026 Jan 8;69(1):439-465.
CoA	CoA of BE2012

Smiles:	O=C1C=2C=CC=CC2N=C(C=3C=CC(=CC3)C(C)(C)C)N1N


		Search