Bcl-2-IN-20

Bcl-2-IN-20 (Compound 81) is an inhibitor for Bcl-2 with IC50 <10 μM (79.1% inhibition at 9 μM). Bcl-2-IN-20 exhibits cytotoxicity in SK-MEL-28 (IC50>10 μM), A549 (IC50=6.1 μM), HepG2 (IC50>10 μM), MCF-7 (IC50=8.9 μM), HCT116 (IC50>10 μM) and HEK-293 (IC50=14.1 μM). Bcl-2-IN-20 promotes the ROS production, induces apoptosis and DNA damage.


Cat. No.: EX-A12967	Purity: >98%

	Chemical structure of Bcl-2-IN-20

For research only, Do not use for Human!

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CAS No.	3049275-84-2
Purity	>98%
Formula	C22H14BrNO6S
Mol Weight	500.319
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Galla MS, et al., Development of chromone-thiazolidine-2,4-dione Knoevenagel conjugates as apoptosis inducing agents. Bioorg Med Chem Lett. 2024 Sep 1;109:129853.
CoA	CoA of Bcl-2-IN-20

Smiles:	O=C1C=2C(=CC(Br)=CC2)OC=C1/C=C\3/C(=O)N(CC(=O)C4=CC=C(OC)C=C4)C(=O)S3


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