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Product Information:

BBO-11818

BBO-11818 is an orally active, highly selective (relative to NRAS and HRAS), non-covalent pan-KRAS inhibitor (IC50=28-120 nM).

Cat. No.: EX-A16698    Purity: >98%
Chemical
Chemical structure of BBO-11818


For research only, Do not use for Human!

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SynonymsBBO11818
CAS No.3029443-36-2
Purity>98%
FormulaC34H33F6N7O3S
Mol Weight733.726
ColorOff-white to light yellow
Statesolid
SolubilityDMSO : 100 mg/mL
Shelf Life>3 years if stored properly
StoragePowder   -20°C, 3 years , 4°C, 2 years ; In solvent-20°C, 6 year
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Stahlhut C, Maciag A E, Sullivan K A, et al. Discovery of BBO-11818, a Potent and Selective Noncovalent Inhibitor of (ON) and (OFF) KRAS with Activity against Multiple Oncogenic Mutants[J]. Cancer Discovery, 2026: OF1-OF20.

[2]. Stahlhut C, et al. Discovery of BBO-11818, a Potent and Selective Noncovalent Inhibitor of (ON) and (OFF) KRAS with Activity against Multiple Oncogenic Mutants. Cancer Discov. Published online March 6, 2026.

CoACoA of BBO-11818
Smiles:CCN([C@H]1CCN(C1)C(OC)=O)C2=NC(OC[C@@]34CCCN3C[C@@H](C4)F)=NC5=C([C@]([C@]6=CC=C(C7=C6C(C#N)=C(S7)N)F)=C(C=C25)C(F)(F)F)F

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