BAM(8-22)

BAM(8-22), a proteolytically cleaved product of proenkephalin A and sensory neuron-specific receptor (SNSR) agonist, is a potent activator of Mas-related G-protein-coupled receptors (Mrgprs), MrgprC11 and hMrgprX1. BAM(8-22) induces scratching in mice in an Mrgpr-dependent manner. In addition, BAM(8-22) has an analgesic effect and can also inhibit the activation of microglia[1][2][3][4].


Cat. No.: EX-A15284	Purity: >98%

	Chemical structure of BAM(8-22)

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
5mg	400	In-stock
10mg	550	In-stock
25mg	800	In-stock
100mg	1150	In-stock

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


Synonyms	BAM8-22
CAS No.	412961-36-5
Purity	>98%
Formula	C91H127N25O23S
Mol Weight	1971.201
Color	White to off-white
State	Solid
Solubility	soluble in H2O
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 1 year, sealed storage, away from moisture; In solvent -20℃, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Wang A, et al. A Novel Mechanism of BAM8-22 Inhibiting Microglia Activation: Represses CX3CR1 Expression via Upregulating miR-184. J Mol Neurosci. 2020 Apr;70(4):550-558. [2]. Liu Q, et al. Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus. Cell. 2009 Dec 24;139(7):1353-65. [3]. Chen T, et al. Modulation of NMDA receptors by intrathecal administration of the sensory neuron-specific receptor agonist BAM8-22. Neuropharmacology. 2008 Apr;54(5):796-803. [4]. Parul Sikand, et al. BAM8-22 peptide produces itch and nociceptive sensations in humans independent of histamine release. J Neurosci. 2011 May 18;31(20):7563-7.
CoA	CoA of BAM(8-22)

Smiles:	CC(C)[C@@H](C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC2=CNC3=CC=CC=C32)C(=O)N[C@@H](CC4=CNC5=CC=CC=C54)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC6=CC=C(C=C6)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCN)C


		Search