β2AR agonist 7

β2AR agonist 7 is a MABA with both muscarinic acetylcholine M3 receptor antagonistic activity and β2-adrenergic receptor agonistic activity, with a Ki of 1.75 nM for hM3 and an EC50 of 0.054 nM for hβ2. β2AR agonist 7 binds to the M3 muscarinic receptor with high affinity and long-acting kinetic characteristics. β2AR agonist 7 induces smooth muscle relaxation and acts as a bronchoprotective agent against acute bronchoconstriction. β2AR agonist 7 can be used in the research of asthma and chronic obstructive pulmonary disease .


Cat. No.: EX-A17361	Purity: >98%

	Chemical structure of β2AR agonist 7

For research only, Do not use for Human!

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CAS No.	3109318-09-1
Purity	>98%
Formula	C46H55N5O7S
Mol Weight	822.023

Reference:	[1].Frojuello Costa Bernstorff Damião MC, et al. Discovery and optimization of diarylsulfone-based dual M-Antagonists and β-Agonists (MABAs) as inhaled bronchodilators. European journal of medicinal chemistry. 2026 Jun 20;317:119082.
CoA	CoA of β2AR agonist 7

Smiles:	C[C@@H](C1=CC=C(S(C2=CC=CC(OCCC(NC3=CC=C(CNC[C@H](O)C4=CC=C(O)C(N5)=C4C=CC5=O)C=C3)=O)=C2)(=O)=O)C=C1)N(CC6)CCN6C7CCCCCC7


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