β-NF-JQ1

β-NF-JQ1 is a PROTAC that recruits Aryl Hydrocarbon Receptor E3 ligase to target proteins. β-NF-JQ1 is directed against bromodomain-containing (BRD) proteins using β-NF as an AhR ligand, induces the interaction of AhR and BRD proteins, and displays effective anticancer activity that correlated with protein knockdown activity .


Cat. No.: EX-A8729	Purity: >98%

	Chemical structure of β-NF-JQ1

For research only, Do not use for Human!

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Synonyms	beta-NF-JQ1
CAS No.	2380000-55-3
Purity	>98%
Formula	C45H42ClN5O6S
Mol Weight	816.363
Color	Off-white to light yellow
State	solid powder
Solubility	DMSO: 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Ohoka N, et al. Development of Small Molecule Chimeras That Recruit AhR E3 Ligase to Target Proteins. ACS chemical biology. 2019 Dec 20;14(12):2822-2832. [2]. Shoda T, et al. Targeted Protein Degradation by Chimeric Compounds using Hydrophobic E3 Ligands and Adamantane Moiety. Pharmaceuticals (Basel, Switzerland). 2020 Feb 25;13(3):34.
CoA	CoA of β-NF-JQ1

Smiles:	O=C(NCCOCCOCCOCC1=CC=C(C2=CC(C3=C(O2)C=CC4=CC=CC=C34)=O)C=C1)C[C@H]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5


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