AZD8421

AZD8421 is a potent and highly selective inhibitor of Cyclin-dependent Kinase 2 (CDK2), with an IC50 against CDK2 of 9nM with selectivity over CDK1, CDK4 and CDK6. It also exhibits an anti-proliferative effect, effectively inhibits Rb phosphorylation, and shows strong activity both as a monotherapy and in combination with CDK4/6 inhibitors in breast and ovarian cancer models.


Cat. No.: EX-A10315	Purity: >98%

	Chemical structure of AZD8421

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
100mg	800	Inquire
1g	2400	Inquire

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CAS No.	3047321-53-6
Purity	>98%
Formula	C18H32N8O3S
Mol Weight	440.563
Color	White to off-white
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Denz C R, et al. Targeting the cell cycle with AZD8421, a potent and highly selective CDK2 inhibitor[J]. Cancer Research, 2024, 84(6_Supplement): 5730-5730.
CoA	CoA of AZD8421

Smiles:	CCN1C=NC2=C1N=C(N[C@@H](CC)[C@@H](C)O)N=C2N[C@@H]3CN(S(=O)(NCC)=O)CC3


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