AZD4573

AZD4573 is a potent inhibitor of CDK9 (IC50 of <0.004 μM) with fast-off binding kinetics (t1/2 = 16 min) and high selectivity versus other kinases, including other CDK family kinases.


Cat. No.: EX-A4269	Purity: >98%

	Chemical structure of AZD4573

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	950	In-stock
250mg	1550	In-stock
500mg	2150	In-stock
1g	3350	In-stock
2g	4900	In-stock
5g	9650	In-stock

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CAS No.	2057509-72-3
Purity	>98%
Formula	C22H28ClN5O2
Mol Weight	429.943
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Bernard Barlaam, et al. Discovery of AZD4573, a potent and selective inhibitor of CDK9 that enables transient target engagement for the treatment of hematologic malignancies. AACR Cancer Res. 2018, 78(13 Suppl):Abstract nr 1650. [2] Justin Cidado, et al. AZD4573, a novel CDK9 inhibitor, rapidly induces cell death in hematological tumor models through depletion of Mcl1. AACR Cancer Res. 2018, 78(13 Suppl):Abstract nr 310.
CoA	CoA of AZD4573

Smiles:	ClC1=CN=C(NC([C@H]2CCC[C@@H](NC(C)=O)C2)=O)C=C1C3=C(CC(C)(C)C4)N4N=C3


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