AZD3778

AZD3778 (Compound 8) is an inhibitor of CCR3 and histamine H1 receptor (histamine H1 receptor), with IC50 values of 8.1 nM and 40 nM, respectively. AZD3778 inhibits the binding of eosinophil chemokines to CCR3, as well as the binding of histamine to histamine H1 receptor. AZD3778 exhibits anti-eosinophilic activity. AZD3778 alleviates symptoms associated with allergic rhinitis. AZD3778 can be used in research related to allergic rhinitis and asthma .


Cat. No.: EX-A8395	Purity: >98%

	Chemical structure of AZD3778

For research only, Do not use for Human!

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Synonyms	AZ 10565259
Synonyms 2	AZD-3778
CAS No.	1032129-23-9
Purity	>98%
Formula	C24H29Cl2N3O4S
Mol Weight	526.476

Reference:	[1].Pease, J.E., et al. Chemokine Receptors in Allergy, Inflammation, and Infectious Disease. In: Tschammer, N. (eds) Chemokines. Topics in Medicinal Chemistry, vol 14. Springer, Cham. [2].Bahl A, et al. The discovery of CCR3/H1 dual antagonists with reduced hERG risk. Bioorg Med Chem Lett. 2012;22(21):6688-6693.
CoA	CoA of AZD3778

Smiles:	O=C(NS(=O)(=O)C1=CC=C(C=C1)C)N2CCC(N3CCC(OC4=CC=C(Cl)C(Cl)=C4)CC3)CC2


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