AZD-3355

Lesogaberan (AZD-3355) is a potent and selective GABAB receptor agonist with an EC50 of 8.6 nM for human recombinant GABAB receptors. The affinity (Kis) of Lesogaberan for rat GABAB and GABAA receptors, as measured by displacement of [ 3H]GABA binding in brain membranes: 5.1 nM and 1.4 μM, respectively. Lesogaberan inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action .


Cat. No.: EX-A8628	Purity: >98%

	Chemical structure of AZD-3355

For research only, Do not use for Human!

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Synonyms	Lesogaberan
CAS No.	344413-67-8
Purity	>98%
Formula	C3H9FNO2P
Mol Weight	141.0812

Reference:	[1].Lehmann A, et al. (R)-(3-amino-2-fluoropropyl) phosphinic acid (AZD3355), a novel GABAB receptor agonist, inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action. J Pharmacol Exp Ther. 2009 Nov;331(2):504-12. [2].Tian J, et al. Repurposing Lesogaberan to Promote Human Islet Cell Survival and β-Cell Replication. J Diabetes Res. 2017;2017:6403539.
CoA	CoA of AZD-3355

Smiles:	O=P(C[C@H](F)CN)O


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