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Product Information:

AZD-0284

AZD-0284 is a selective inverse agonist of the nuclear receptor RORγ. AZD-0284 has the potential for plaque psoriasis vulgaris and respiratory tract disorders treatment.

Cat. No.: EX-A5140    Purity: >99%
Chemical
Chemical structure of AZD-0284


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg374in_stock
250mg584in_stock
500mg878in_stock
1g1314in_stock


SynonymsRelated CAS 2101291-12-5
CAS No.2101291-07-8
Purity>99%
FormulaC21H18F6N2O5S
Mol Weight524.433
ColorWhite to off-white
Statesolid powder
SolubilitySoluble in DMSO 100 mg/mL
Shelf Life>3 years if stored properly
StoragePowder 4°C, stored under nitrogen; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Narjes, F, et al. The discovery of AZD0284, an inverse agonist of the nuclear receptor RORg. American Chemical Society, 2017 Drug Design and Delivery Symposium 26 October 2017

[2]. Asimus S, et al. Pharmacokinetics, pharmacodynamics and safety of the inverse retinoic acid-related orphan receptor γ agonist AZD0284 [published online ahead of print, 2020 Feb 17]. Br J Clin Pharmacol. 2020;10.1111/bcp.14253.
CoACoA of AZD-0284
Smiles:CC(N1CC2=C(C=CC(S(=O)(C)=O)=C2)[C@@H]1C(NC3=CC=C(C(C(F)(F)F)(O)C(F)(F)F)C=C3)=O)=O

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