background


Product Information:

AZ960

AZ960 is a potent and specific inhibitor of the JAK2 kinase with a Ki of 0.45 nM.

Cat. No.: EX-A1802    Purity: >98%
Chemical
Chemical structure of AZ960


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
50mg565In-stock
100mg865In-stock
200mg1265In-stock
500mg1965In-stock
1g3165In-stock
5g9695Inquire


SynonymsAZ-960
CAS No.905586-69-8
Purity>98%
FormulaC18H16F2N6
Mol Weight354.3566
Statesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Ikezoe T, et al. Expression of p-JAK2 predicts clinical outcome and is a potential molecular target of acute myelogenous leukemia. Int J Cancer. 2011 Nov 15;129(10):2512-21.

[2]. Gozgit JM, et al. Effects of the JAK2 inhibitor, AZ960, on Pim/BAD/BCL-xL survival signaling in the human JAK2 V617F cell line SET-2. J Biol Chem. 2008 Nov 21;283(47):32334-43.

[3]. Yang J, et al. AZ960, a novel Jak2 inhibitor, induces growth arrest and apoptosis in adult T-cell leukemia cells. Mol Cancer Ther. 2010 Dec;9(12):3386-95.

[4]. Valenciano AL, et al. Discovery and antiparasitic activity of AZ960 as a Trypanosoma brucei ERK8 inhibitor. Bioorg Med Chem. 2016 Oct 1;24(19):4647-51.

CoACoA of AZ960
Smiles:C[C@H](NC1=NC(NC2=NNC(C)=C2)=C(F)C=C1C#N)C1=CC=C(F)C=C1

KEYWORDS: buy AZ960 | AZ960 supplier | purchase | cost | manufacturer | order | distributor | buy 905586-69-8 | 905586-69-8 supplier