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Product Information:

AZ20

AZ20 is a potent and selective inhibitor of ATR with an IC50 of 5 nM, and has 8-fold selectivity against mTOR (IC50=38 nM).

Cat. No.: EX-A1801    Purity: >98%
Chemical
Chemical structure of AZ20


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
500mg825In-stock
1g1450In-stock
2g2450In-stock
5g4825In-stock
10g6825In-stock


CAS No.1233339-22-4
Purity>98%
FormulaC21H24N4O3S
Mol Weight412.505
Statesolid powder
SolubilityDMSO : >50 mg/mL (242.48 mM)
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Foote KM, et al. Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity. J Med Chem. 2013 Mar 14

CoACoA of AZ20
Smiles:C[C@@H]1COCCN1C1=NC(=NC(=C1)C1(CC1)S(C)(=O)=O)C1=C2C=CNC2=CC=C1

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