AZ1495

AZ1495 (compound 28) is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively. Shows activity in treatment of mutant MYD88L265P diffuse large B-cell lymphoma (DLBCL).


Cat. No.: EX-A3726	Purity: >98%

	Chemical structure of AZ1495

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	435	In-stock
250mg	685	In-stock
500mg	885	In-stock
1g	1450	In-stock
5g	5075	In-stock

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Synonyms	IRAK4-IN-3
CAS No.	2196204-23-4
Purity	>98%
Formula	C21H31N5O2
Mol Weight	385.5031
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Scott JS, et al. Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88L265P Diffuse Large B-Cell Lymphoma. J Med Chem. 2017 Dec 28;60(24):10071-10091.
CoA	CoA of AZ1495

Smiles:	C1(C(C2CCOCC2)=CN3)=C3N=CN=C1N[C@@H]4CC[C@@H](N5CCOCC5)CC4


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