Aurora kinase HDAC-IN-1

Aurora kinase/HDAC-IN-1 is an orally active dual Aurora kinase and HDAC inhibitor that inhibits Aurora A (IC50 = 116 nM), Aurora B (IC50 = 225 nM), HDAC1 (IC50 = 164 nM), and HDAC2 (IC50 = 346 nM).Aurora kinase/HDAC-IN-1 promotes histone H3 acetylation, inhibits Aurora A phosphorylation and downstream signaling, and induces apoptosis via G2/M cell-cycle arrest. Aurora kinase/HDAC-IN-1 exhibits potent antiproliferative activity in colorectal cancer cells, with an IC50 value of 30.2 nM in HCT-116 cells.Aurora kinase/HDAC-IN-1 significantly suppresses tumor growth in an HCT-116 colorectal cancer xenograft mouse model.


Cat. No.: EX-A16510	Purity: >98%

	Chemical structure of Aurora kinase HDAC-IN-1

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
25mg	996	inquire
100mg	1598	inquire

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CAS No.	2727102-12-5
Purity	>98%
Formula	C22H20FN7OS
Mol Weight	449.504
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Cui H, et al. Design and Synthesis of Novel N-(1H-pyrazol-3-yl)pyrimidin-4-amine Aurora/HDAC Dual Inhibitors for Colorectal Cancer Treatment. J Med Chem. 2025;68(22):23941-23961. doi:10.1021/acs.jmedchem.5c01321
CoA	CoA of Aurora kinase HDAC-IN-1

Smiles:	O=C(C1=CC=C(CSC2=NC=CC(NC3=NNC(C)=C3)=N2)C=C1)NC4=CC=C(C=C4N)F


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