AUR-1545

AUR1545 is a selective KAT2A/KAT2B ((GCN5/PCAF)) PROTAC degrader that induces monocyte differentiation and inhibits the growth of acute myeloid leukemia cells. AUR1545 inhibits cell growth, induces epithelial differentiation and suppresses tumor growth in small cell lung cancer models. AUR1545 inhibits cell growth and induces differentiation in neuroendocrine prostate cancer cells and primary patient-derived organoids. AUR1545 is applicable to research related to acute myeloid leukemia, small cell lung cancer and neuroendocrine prostate cancer.


Cat. No.: EX-A13108	Purity: >98%

	Chemical structure of AUR-1545

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	995	in-stock
100mg	1680	in-stock
250mg	2680	in-stock

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CAS No.	3031593-79-7
Purity	>98%
Formula	C41H50BrN9O5
Mol Weight	828.797
Color	Off-white to light yellow
State	Solid
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Straley K S, et al. Potent and selective degradation of KAT2A and KAT2B induces profound cell state changes and inhibits growth of AML, SCLC and NEPC model systems[J]. Cancer Research, 2024, 84(6_Supplement): 5795-5795.
CoA	CoA of AUR-1545

Smiles:	O=C1C=2C(CN1C3C(=O)NC(=O)CC3)=CC(=CC2)N4CCN(CC5CCN(C(=O)C6=CC=C(C=C6)[C@H]7C[C@@H](NC8=C(Br)C(=O)N(C)N=C8)CN(C)C7)CC5)CC4


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