AU-24118

AU-24118 is a selective and orally bioavailable PROTAC degrader of mSWI-SNF ATPases (SMARCA2 and SMARCA4) and PBRM1. AU-24118 integrates a bait moiety binding to the bromodomains of SMARCA2 and SMARCA4, along with a ligand moiety for CRBN ligase. AU-24118 demonstrates tumor regression in prostate cancer model. AU-24118 can be studied to combat prostate cancer.


Cat. No.: EX-A13119	Purity: >98%

	Chemical structure of AU-24118

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
5mg	460	In-stock
10mg	860	In-stock
25mg	1560	In-stock
50mg	2680	In-stock

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Purity	>98%
Formula	C37H40N6O4
Mol Weight	632.7513
Color	Light yellow to brown
State	Solid
Solubility	DMSO : 8.33 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Tongchen He, et al. Development of an orally bioavailable mSWI/SNF ATPase degrader and acquired mechanisms of resistance in prostate cancer. bioRxiv [Preprint]. 2024 Mar 2:2024.02.29.582768.
CoA	CoA of AU-24118

Smiles:	NC1=C(C=C(N=N1)C2=C(C=CC=C2)O)C3=CC=C(C=C3)N4CCC(CC4)N5CCC(CC5)C6=CC=C(C=C6)OC7CCC(NC7=O)=O


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