ATX inhibitor 27

ATX inhibitor 27 (Compound 31) is an ATX inhibitor. The IC50 values of ATX inhibitor 27 against human autotaxin (hATX) and lysophosphatidylcholine (LPC) are 13 nM and 23 nM, respectively. ATX inhibitor 27 reduces LPA levels in vivo by inhibiting ATX enzyme. ATX inhibitor 27 can be used in the study of ATX-LPA-related diseases such as inflammation, neurodegenerative diseases and cancer .


Cat. No.: EX-A15552	Purity: >98%

	Chemical structure of ATX inhibitor 27

For research only, Do not use for Human!

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CAS No.	2023027-81-6
Purity	>98%
Formula	C26H26ClN5O3
Mol Weight	491.969
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Martin RE, et al. Optimization of a DNA encoded library derived autotaxin inhibitor hit to a potent in vivo LPA lowering quinazolinone compound with a non‑zinc binding mode. Bioorg Med Chem Lett. 2025 Aug 1;123:130221.
CoA	CoA of ATX inhibitor 27

Smiles:	CC(N1CCC(C2=CC3=C(N=CN(CC(N(C)CC4=CC=C(C#N)C(Cl)=C4)=O)C3=O)C=C2)CC1)=O


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