ATX inhibitor 26

ATX inhibitor 26 is an Autotaxin (ATX) inhibitor with an IC50 of 57 nM in human plasma. ATX inhibitor 26 inhibits cell migration and collagen gel contraction. ATX inhibitor 26 has significant anti-fibrotic effects, reducing collagen deposition in a Bleomycin (BLM) -induced pulmonary fibrosis model .


Cat. No.: EX-A15551	Purity: >98%

	Chemical structure of ATX inhibitor 26

For research only, Do not use for Human!

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CAS No.	2940248-11-1
Purity	>98%
Formula	C18H19Cl2N7O3
Mol Weight	452.295
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Kim M, et al. Targeting Autotaxin with imidazole- and Triazolyl-based inhibitors: Biological insights from in vitro and in vivo studies in pulmonary fibrosis. Bioorg Chem. 2025 Jun 15; 160:108426.
CoA	CoA of ATX inhibitor 26

Smiles:	ClC1=CC(Cl)=CC(COC(N2CCC(C3=NN=C(NCC4=CN=NN4)O3)CC2)=O)=C1


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