background


Product Information:

Atiprimod dihydrochloride

Atiprimod hydrochloride (SKF 106615) is an orally active immunomodulatory agent that causes phospholipid (PL) accumulation in macrophages[1].

Cat. No.: EX-A15288    Purity: >98%
Chemical
Chemical structure of Atiprimod dihydrochloride


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
1gget quote
5gget quote


SynonymsAzaspirane hydrochloride
Synonyms 2SKF 106615-12 hydrochloride
CAS No.130065-61-1
Purity>98%
FormulaC22H46Cl2N2
Mol Weight409.52
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Coker-Gurkan A, et al. Atiprimod induce apoptosis in pituitary adenoma: Endoplasmic reticulum stress and autophagy pathways. J Cell Biochem. 2019 Dec;120(12):19749-19763.

[2]. Coker-Gurkan A, et al Atiprimod triggered apoptotic cell death via acting on PERK/eIF2α/ATF4/CHOP and STAT3/NF-ΚB axis in MDA-MB-231 and MDA-MB-468 breast cancer cells. Mol Biol Rep. 2021 Jun;48(6):5233-5247.

[3]. Faderl S, et al. Atiprimod blocks phosphorylation of JAK-STAT and inhibits proliferation of acute myeloid leukemia (AML) cells. Leuk Res. 2007 Jan;31(1):91-5.

[4]. Wang M, et al. Atiprimod inhibits the growth of mantle cell lymphoma in vitro and in vivo and induces apoptosis via activating the mitochondrial pathways. Blood. 2007 Jun 15;109(12):5455-62.

[5]. Hamasaki M, et al. Azaspirane (N-N-diethyl-8,8-dipropyl-2-azaspiro [4.5] decane-2-propanamine) inhibits human multiple myeloma cell growth in the bone marrow milieu in vitro and in vivo. Blood. 2005 Jun 1;105(11):4470-6.

[6]. Quintás-Cardama A, et al. Preclinical characterization of atiprimod, a novel JAK2 AND JAK3 inhibitor. Invest New Drugs. 2011 Oct;29(5):818-26.

CoACoA of Atiprimod dihydrochloride
Smiles:CCCC1(CCC2(CC1)CCN(C2)CCCN(CC)CC)CCC.Cl.Cl

KEYWORDS: buy Atiprimod dihydrochloride | Atiprimod dihydrochloride supplier | purchase | cost | manufacturer | order | distributor | buy 130065-61-1 | 130065-61-1 supplier