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Product Information:

AS-0141

AS-0141 is a potent Cdc7 kinase inhibitor (IC50=4 nM) extracted from patent WO2019165473A1(compound I- D) with anti-tumor activity.

Cat. No.: EX-A8343    Purity: >98%
Chemical
Chemical structure of AS-0141


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
50mg522in_stock
100mg836in_stock
250mg2065in_stock
1g2918in_stock


SynonymsMonzosertib
Synonyms 2SRA141
CAS No.1402057-88-8
Purity>98%
FormulaC21H22F3N5O4
Mol Weight465.4257
Statesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Takayuki Irie, et al. Discovery of AS-0141, a Potent and Selective Inhibitor of CDC7 Kinase for the Treatment of Solid Cancers. J Med Chem. 2021 Oct 14;64(19):14153-14164.

[2]. Christian Andrew HASSIG, et al. Methods of treatment of cancer comprising cdc7 inhibitors. WO2019165473A1.

CoACoA of AS-0141
Smiles:O=C(C(C/1=O)=C(NN2CCN(CC(F)(F)F)CC2)OC1=C/C3=CNC4=C3C=CC=N4)OCC

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