Artepillin C

Artepillin C is an orally active CREB/CRTC2 inhibitor and TRPA1 covalent agonist (EC50=1.8 μM). Artepillin C inhibits CREB/CRTC2-mediated gene transcription and downregulates BMAL1 expression to regulate glucose and lipid metabolism. Artepillin C can also activate TRPA1 channels to induce spicy taste signals. Artepillin C can inhibit tumor cell proliferation, induce necroptosis, improve insulin resistance and inhibit liver lipid synthesis. Artepillin C can be used in the study of metabolic syndrome, tumor prevention and treatment, and inflammation[1][2][3][4].


Cat. No.: EX-A14881	Purity: >98%

	Chemical structure of Artepillin C

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
25mg	656	In-stock
50mg	1048	In-stock
100mg	1712	In-stock
250mg	2540	In-stock

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CAS No.	72944-19-5
Purity	>98%
Formula	C19H24O3
Mol Weight	300.3921
Color	Light yellow to yellow
State	Solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃, 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Kobal MB,et al. Correlating Artepillin C cytotoxic activity on HEp-2 cells with bioinspired systems of plasma membranes. Mater Sci Eng C Mater Biol Appl. 2020 Jul;112:110943. [2]. Ahn MR, et al. Suppression of tumor-induced angiogenesis by Brazilian propolis: major component artepillin C inhibits in vitro tube formation and endothelial cell proliferation. Cancer Lett. 2007 Jul 18;252(2):235-43. [3]. Hata T, et al. Artepillin C, a major ingredient of Brazilian propolis, induces a pungent taste by activating TRPA1 channels. PLoS One. 2012;7(11):e48072. [4]. Wang L, et al. Artepillin C Time-Dependently Alleviates Metabolic Syndrome in Obese Mice by Regulating CREB/CRTC2-BMAL1 Signaling. Nutrients. 2023 Mar 28;15(7):1644.
CoA	CoA of Artepillin C

Smiles:	CC(=CCC1=CC(=CC(=C1O)CC=C(C)C)/C=C/C(=O)O)C


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