ART899

ART899 (ART-899) is a potent, specific allosteric inhibitor of DNA polymerase theta (Polθ), specifically inhibits Polθ MMEJ activity with IC50 of 180 nM, shows with improved in vivo stability compared to ART558.


Cat. No.: EX-A10451	Purity: >98%

	Chemical structure of ART899

For research only, Do not use for Human!

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Synonyms	ART-899
CAS No.	2607139-85-3
Purity	>98%
Formula	C19H16ClF4N3O4
Mol Weight	464.813
Color	White to off-white
State	Solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years, 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Gonzalo Rodriguez-Berriguete, et al. Clin Cancer Res. 2023 Jan 23;CCR-22-2977.
CoA	CoA of ART899

Smiles:	C(N(C([2H])([2H])[2H])C1=CC(Cl)=C(F)C=C1)(=O)[C@H]2N(C(=O)[C@@H](O)[C@H]2O)C3=CC(C(F)(F)F)=CC(C)=N3


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