ART812

ART812 is an orally active DNA polymerase Polθ inhibitor with an IC50 value of 7.6 nM. ART812 has an IC50 value of 240 nM for cell based microhomology-mediated end joining (MMEJ).


Cat. No.: EX-A8350	Purity: >98%

	Chemical structure of ART812

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
25mg	476	in_stock
50mg	688	in_stock
100mg	1035	in_stock
250mg	1528	in_stock
500mg	2126	in_stock
1g	2949	in_stock

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Synonyms	ART-812
CAS No.	2607138-82-7
Purity	>98%
Formula	C19H16ClF4N3O4
Mol Weight	461.795
Color	White to yellow
State	solid powder
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Zatreanu D, et al. Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance. Nat Commun. 2021 Jun 17;12(1):3636. [2]. Peter BLENCOWE, et al. Preparation of heterocyclic compounds for use in the treatment of cancer. WO2021028643 A1.
CoA	CoA of ART812

Smiles:	CN(C1=CC(Cl)=C(C=C1)F)C([C@H]2N(C3=CC(C(F)(F)F)=CC(C)=N3)C([C@H]([C@H]2O)O)=O)=O


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