ART558

ART558 is a nanomolar potent, selective, low molecular weight, allosteric DNA polymerase activity of Polθ inhibitor (IC50=7.9 nM). ART558 can be used for the research of cancer.


Cat. No.: EX-A5345	Purity: >98%

	Chemical structure of ART558

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	473	in_stock
100mg	717	in_stock
250mg	1222	in_stock
500mg	1830	in_stock
1g	2715	in_stock

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CAS No.	2603528-97-6
Purity	>98%
Formula	C21H21F3N4O2
Mol Weight	418.4122
Color	White to off-white
State	solid powder
Solubility	Soluble in DMSO 170 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder 4°C, sealed storage, away from moisture and light; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Zatreanu D, et al. Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance. Nat Commun. 2021 Jun 17;12(1):3636.
CoA	CoA of ART558

Smiles:	CN(C1=CC(C)=CC=C1)C([C@H]2N(C3=C(C(C(F)(F)F)=CC(C)=N3)C#N)CC[C@H]2O)=O


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