ARB-272572

ARB-272572 is an oral effective small molecule PD-L1 inhibitor, with an IC50 value of 400 pM. ARB-272572 has research significance in tumors and chronic viral infections .


Cat. No.: EX-A10227	Purity: >98%

	Chemical structure of ARB-272572

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
25mg	340	In-stock
50mg	530	In-stock
100mg	820	In-stock
250mg	1580	In-stock
500mg	2500	In-stock
1g	3800	In-stock

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CAS No.	2368182-63-0
Purity	>98%
Formula	C32H36N6O4
Mol Weight	568.666
Color	white to off-white
State	solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ 2 years, protect from light; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Park JJ, et al. Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1. Nat Commun. 2021 Feb 22;12(1):1222. [2]. Zhijie Wang, et al. Reducing PD-L1 Expression by Degraders and Downregulators as a Novel Strategy to Target the PD-1/PD-L1 Pathway. J Med Chem. 2024 Apr 25;67(8):6027-6043.
CoA	CoA of ARB-272572

Smiles:	CC1=C(C=CC=C1C2=CC=CC(NC(C3=NC=C(C=C3)CNCCO)=O)=C2C)NC(C4=CC=C(C=N4)CNCCO)=O


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