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Product Information:

APX001

APX001 is a prodrug of APX-001A, the first-in-class inhibitor of the fungal protein Gwt1.

Cat. No.: EX-A5184    Purity: >98%
Chemical
Chemical structure of APX001


For research only, Do not use for Human!

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SynonymsFosmanogepix
Synonyms 2E1211
CAS No.1169701-00-1
Purity>98%
FormulaC22H21N4O6P
Mol Weight468.3991
Statesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Shaw KJ, et al. In Vitro and In Vivo Evaluation of APX001A/APX001 and Other Gwt1 Inhibitors against Cryptococcus. Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e00523-18.

[2]. Gebremariam T, et al. APX001 Is Effective in the Treatment of Murine Invasive Pulmonary Aspergillosis. Antimicrob Agents Chemother. 2019 Jan 29;63(2). pii: e01713-18.
CoACoA of APX001
Smiles:C1=CC=NC(=C1)OCC2=CC=C(C=C2)CC3=NOC(=C3)C4=C([N+](=CC=C4)COP(=O)(O)[O-])N

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