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Product Information:

APX-115

APX-115 is a first-in-class, orally active, pan-NADPH oxidase (Nox) inhibitor with Ki of 1.08, 0.57, 0.63 nM for Nox1, Nox2, and Nox4, respectively

Cat. No.: EX-A4040A    Purity: >98%
Chemical
Chemical structure of APX-115


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
50mg550In-stock
100mg850In-stock
200mg1185In-stock
1g2300Inquire


SynonymsEwha-18278
CAS No.1395946-75-4
Purity>98%
FormulaC17H18ClN3O
Mol Weight315.797
ColorLight yellow to yellow
Statesolid powder
SolubilitySoluble in DMSO 100 mg/mL
Shelf Life>3 years if stored properly
StoragePowder 4°C, sealed storage, away from moisture; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  JH Joo et al. A novel pyrazole derivative protects from ovariectomy-induced osteoporosis through the inhibition of NADPH oxidase. Sci Rep. 2016 Mar 15;6:22389.

JJ Cha et al. APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury. Lab Invest. 2017 Apr;97(4):419-431.
CoACoA of APX-115

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