APG-115

Alrizomadlin (APG-115) is an orally active MDM2 protein inhibitor binding to MDM2 protein with IC50 and Ki values of 3.8 nM and 1 nM, respectively. Alrizomadlin blocks the interaction of MDM2 and p53 and induces cell-cycle arrest and apoptosis in a p53-dependent manner.


Cat. No.: EX-A7190	Purity: >98%

	Chemical structure of APG-115

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	501	in_stock
250mg	1022	in_stock
500mg	1625	in_stock
1g	2737	in_stock

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Synonyms	Alrizomadlin
Synonyms 2	AA-115
CAS No.	1818393-16-6
Purity	>98%
Formula	C34H38Cl2FN3O4
Mol Weight	642.588
Color	White to off-white
State	solid powder
Solubility	Soluble in DMSO 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Angelo Aguilar, et al. 4-((3'R,4'S,5'R)-6″-Chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2″-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3″-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Do [2]. A W Tolcher et al, A phase Ib/II study of APG-115 in combination with MK-3475 in patients with unresectable or metastatic melanomas or advanced solid tumors, Ann Oncol. 2019 Feb 1; 30(Supplement_1). pii: mdz027. [3]. Hanjie Yi ea al, A novel small molecule inhibitor of MDM2-p53 (APG-115) enhances radiosensitivity of gastric adenocarcinoma, J Exp Clin Cancer Res. 2018 May 2;37(1):97. [4]. Chen H, et al. Restoration of p53 using the novel MDM2-p53 antagonist APG115 suppresses dedifferentiated papillary thyroid cancer cells. Oncotarget. 2017 Jun 27;8(26):43008-43022.
CoA	CoA of APG-115

Smiles:	O=C1[C@]2(C3=CC=C(Cl)C=C3N1)C4(CCCCC4)N([C@H]([C@@H]2C5=C(C(Cl)=CC=C5)F)C(NC67CCC(CC6)(CC7)C(O)=O)=O)CC


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