AP-4-139B

AP-4-139B is a blood-brain barrier-permeable HSP70 inhibitor with a IC50 of 180 nM against hHSP70. AP-4-139B binds directly to HSP70 and inhibits its ATPase activity. AP-4-139B promotes Autophagy by increasing the phosphorylation of Beclin-1. AP-4-139B exerts antitumor effects in preclinical models of colorectal cancer and pancreatic ductal adenocarcinoma.


Cat. No.: EX-A13200	Purity: >98%

	Chemical structure of AP-4-139B

For research only, Do not use for Human!

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CAS No.	2716909-84-9
Purity	>98%
Formula	C34H33BrN3PS
Mol Weight	626.589
Color	White to off-white
State	Solid
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, sealed storage, away from moisture; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Barnoud T, et al. A Novel Inhibitor of HSP70 Induces Mitochondrial Toxicity and Immune Cell Recruitment in Tumors. Cancer Res. 2020;80(23):5270-5281. [2]. Ferretti GDS, et al. HSP70-mediated mitochondrial dynamics and autophagy represent a novel vulnerability in pancreatic cancer. Cell Death Differ. 2024;31(7):881-896.
CoA	CoA of AP-4-139B

Smiles:	[Br-].N=1C(=CN2N=C(SC12)CCCCCC[P+](C=3C=CC=CC3)(C=4C=CC=CC4)C=5C=CC=CC5)C=6C=CC=CC6


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