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Product Information:

Antitumor agent-138

Antitumor agent-138 (compound 5b) is an inhibitor against tubulin polymerization at tubulin colchicine-binding sites, with IC50 of 1.87 μM. Antitumor agent-138 arrests the cell cycle at G2/M phase and induces an apoptosis in MCF-7 cells. Antitumor agent-138 inhibits cells migration and angiogenesis.

Cat. No.: EX-A8781    Purity: >98%
Chemical
Chemical structure of Antitumor agent-138


For research only, Do not use for Human!

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CAS No.2975168-22-8
Purity>98%
FormulaC20H21N3O4
Mol Weight367.3984
 
 
Reference:  

[1]. Yang Y, et al., Design and synthesis of novel 3-amino-5-phenylpyrazole derivatives as tubulin polymerization inhibitors targeting the colchicine-binding site. Eur J Med Chem. 2024 Jan 24;267:116177.

CoACoA of Antitumor agent-138
Smiles:CC1=CC=C(C2=CC(N)=NN2C(C3=CC(OC)=C(OC)C(OC)=C3)=O)C=C1

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