Antitumor agent-100 hydrochloride

Antitumor agent-100 (compound A6) hydrochloride is an orally potent apoptosis inducer and molecular gel targeting PDE3A-SLFN12 (IC50: 0.3 μM) with antitumor activity. Antitumor agent-100 hydrochloride binds to the PDE3A enzyme pocket to recruit and stabilize SLFN12, thereby preventing protein translation and leading to apoptosis.


Cat. No.: EX-A17106	Purity: >98%

	Chemical structure of Antitumor agent-100 hydrochloride

For research only, Do not use for Human!

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CAS No.	2841750-53-4
Purity	>98%
Formula	C17H15Cl2N3O
Mol Weight	348.227
State	Solid
Shelf Life	>3 years if stored properly
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Jie Chen, et al. Structure of PDE3A-SLFN12 complex and structure-based design for a potent apoptosis inducer of tumor cells. Nat Commun. 2021 Oct 27;12(1):6204.
CoA	CoA of Antitumor agent-100 hydrochloride

Smiles:	O=C1N=C2NC3=C(CN2C1)C(Cl)=C(C4=CC=C(C)C=C4)C=C3.Cl


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