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Product Information:

Anticancer agent 235

Anticancer agent 235 (Compound 49) is a modulator for PI3K/AKT/mTOR pathway, that promotes the generation of ROS, reduces the mitochondrial membrane potential, and thereby inhibits the proliferation of cancer cells HCT116, Caco-2, AGS and SMMC-772 with IC50 of 0.35-26.9 μM. Anticancer agent 235 arrests the cell cycle at G2/M phase, and induces apoptosis in HCT116 .

Cat. No.: EX-A17340    Purity: >98%
Chemical
Chemical structure of Anticancer agent 235


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
5mg682Inquire
10mg825Inquire
25mg1256Inquire


CAS No.2411108-21-7
Purity>98%
FormulaC17H13ClN2O
Mol Weight296.751
 
 
Reference:  

[1].Ma Y, et al. Synthesis and Biological Activity of 2-Chloro-8-methoxy-5-methyl-5 H-indolo [2, 3-b] Quinoline for the Treatment of Colorectal Cancer by Modulating PI3K/AKT/mTOR Pathways[J]. ACS Omega, 2024.

CoACoA of Anticancer agent 235
Smiles:CN1C2=NC3=CC(OC)=CC=C3C2=CC4=C1C=CC(Cl)=C4

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