Anti-inflammatory agent 79

Anti-inflammatory agent 79 (compound 17q) is an isoquinolinone derivative-based HIF-1 inhibitor (IC50: 0.55 μM), which can effectively block HIF-1 signals and increase HIF- Degradation of 1α. Anti-inflammatory agent 79 inhibits synovial invasion and migration and inhibits angiogenesis. Anti-inflammatory agent 79 also effectively reduced foot swelling and arthritis in a mouse inflammation model, and down-regulated the levels of inflammatory factors and blood vessel proliferation in the body.


Cat. No.: EX-A12947	Purity: >98%

	Chemical structure of Anti-inflammatory agent 79

For research only, Do not use for Human!

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CAS No.	3057738-35-6
Purity	>98%
Formula	C21H17NO2
Mol Weight	315.3652
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Cai L, et al. Discovery of novel diaryl substituted isoquinolin-1(2H)-one derivatives as hypoxia-inducible factor-1 signaling inhibitors for the treatment of rheumatoid arthritis. Eur J Med Chem. 2024 Apr 16;271:116417.
CoA	CoA of Anti-inflammatory agent 79

Smiles:	O=C1C2=CC=C(C=C2C=CN1CCC=3C=CC=CC3)C4=COC=C4


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