AN6001

AN6001 is a potent and highly selective small-molecule positive allosteric modulator (PAM) targeting $\alpha6\beta2^*$-containing nicotinic acetylcholine receptors (nAChRs). It has emerged as a promising tool compound in biomedical and neuroscience research, drawing substantial interest for its unique subunit-specific selectivity and robust neuroprotective efficacy.


Cat. No.: EX-A16199	Purity: >98%

	Chemical structure of AN6001

For research only, Do not use for Human!

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CAS No.	1097120-63-2
Purity	>98%
Formula	C21H15Cl2FN4O4S
Mol Weight	509.338

Reference:	[1]. van Hout, Marloes et al. “Characterization of AN6001, a positive allosteric modulator of α6β2-containing nicotinic acetylcholine receptors.” Biochemical pharmacology vol. 174 (2020): 113788. doi:10.1016/j.bcp.2019.113788. [2]. Smith, Alexander R., and Maria G. Silva. "Recent Advances and Subtype Selectivity of Heteromeric Nicotinic Acetylcholine Receptor Ligands." Pharmacological Research, vol. 189, Mar. 2023, pp. 104-118. ScienceDirect, doi:10.1016/j.phrs.2023.106650. [3].European Consortium for Neuropharmacology. "alpha6 Nicotinic Acetylcholine Receptors: A Pharmacological Challenge and Breakthrough." Authorea, 20 Aug. 2025, v1. Authorea Database, doi:10.22541/au.175569060.03472549/v1
CoA	CoA of AN6001

Smiles:	C(=C(/C(NS(C)(=O)=O)=O)\C#N)\C=1C(=NN(C1)C2=CC(Cl)=C(OC)C=C2)C3=CC(F)=C(Cl)C=C3


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