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Product Information:

AMPTX-1

AMPTX-1, a molecular glue, a potent and selective, reversibly covalent BRD9 degrader via recruitment of BRD9 to the E3 ligase DCAF16 .

Cat. No.: EX-A16288    Purity: >98%
Chemical
Chemical structure of AMPTX-1


For research only, Do not use for Human!

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CAS No.3033019-04-1
Purity>98%
FormulaC42H53N5O4
Mol Weight691.9013
Colorwhite to off-white
Statesolid
Solubilitysoluable in DMSO
Shelf Life>3 years if stored properly
StoragePowder 4℃, 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Scott J. Hughes, et al. Selective degradation of BRD9 by a DCAF16-recruiting targeted glue: mode of action elucidation and in vivo proof of concept. bioRxiv. January 02, 2025.

CoACoA of AMPTX-1
Smiles:N#CC(=CC(C)(C)C)C(=O)N1CCC=2C(=CC=CC2C1C)CN3CCN(CC=4C(OC)=CC(=CC4OC)C5=CN(C(=O)C(=C5C)C)C)CC36CC6

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