AMPK activator 16

AMPK activator 16 (compound 6) is a AMP-activated protein kinase (AMPK) inhibitor. AMPK activator 16 shows the most efficient interactions with the key residues of AMPK and demonstrates significant activation of AMPK. AMPK activator 16 increases the expression of phosphorylated AMPK (p-AMPK) and its downstream signaling proteins, such as phosphorylated ACC (Acetyl-CoA Carboxylase) (p-ACC) and phosphorylated raptor (p-raptor), in N2a cells.


Cat. No.: EX-A12400	Purity: >98%

	Chemical structure of AMPK activator 16

For research only, Do not use for Human!

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CAS No.	2252336-04-0
Purity	>98%
Formula	C23H20ClNO5S
Mol Weight	457.927
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Jeon KH, et al. Computer-aided discovery of novel AMPK activators through virtual screening and SAR-driven synthesis. Eur J Med Chem. 2025 Apr 5;287:117318.
CoA	CoA of AMPK activator 16

Smiles:	C(=C/C(=O)C1=CC=C(NS(=O)(=O)C2=CC=C(Cl)C=C2)C=C1)\C3=C(OC)C=CC(OC)=C3


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