AMG7905

AMG 7905 is a hypothermia-inducing transient receptor potential vanilloid type 1 (TRPV1) antagonist. AMG 7905 potentiates TRPV1 channels activation by protons and drives the reflectory inhibition of thermogenesis and tail-skin vasoconstriction, while potently blocking channel activation by capsaicin .


Cat. No.: EX-A9353	Purity: >98%

	Chemical structure of AMG7905

For research only, Do not use for Human!

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CAS No.	1026876-55-0
Purity	>98%
Formula	C25H24F3N5S
Mol Weight	483.552
Color	Light yellow to yellow
State	Solid
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Garami A, et al. TRPV1 antagonists that cause hypothermia, instead of hyperthermia, in rodents: Compounds' pharmacological profiles, in vivo targets, thermoeffectors recruited and implications for drug development. Acta Physiol (Oxf). 2018 Jul;223(3):e13038. [2]. Lehto SG, et al. Antihyperalgesic effects of (R,E)-N-(2-hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)-acrylamide (AMG8562), a novel transient receptor potential vanilloid type 1 modulator that does not cause hyperthermia in rats. J Pharmacol Exp Ther. 2008 Jul;326(1):218-29.
CoA	CoA of AMG7905

Smiles:	FC(C1=CC=C(C2=CC(NC3=CC=C4N=CSC4=C3)=NC=N2)C(NCC5CCCCC5)=C1)(F)F


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