AMG PERK 44

AMG PERK 44 is an orally active and highly selective PERK inhibitor with an IC50 of 6 nM. AMG PERK 44 has 1000-fold and 160-fold selectivity over GCN2 (IC50=7300 nM) and B-Raf (IC50 >1000 nM), respectively. AMG PERK 44 induces autophagy[1][2].


Cat. No.: EX-A14560	Purity: >98%

	Chemical structure of AMG PERK 44

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	506	in_stock
250mg	1001	in_stock
500mg	1560	in_stock
1g	2521	in_stock
2g	3929	in_stock
3g	4759	in_stock

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CAS No.	1883548-84-2
Purity	>98%
Formula	C34H29ClN4O2
Mol Weight	561.073
Color	Light yellow to yellow
State	Solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, sealed storage, away from moisture; In solvent -20°C, 6 months;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Smith AL, et al. Discovery of 1H-pyrazol-3(2H)-ones as potent and selective inhibitors of protein kinase R-like endoplasmic reticulum kinase (PERK). J Med Chem. 2015 Feb 12;58(3):1426-41. [2]. Roest G, et al. The ER Stress Inducer l-Azetidine-2-Carboxylic Acid Elevates the Levels of Phospho-eIF2α and of LC3-II in a Ca2+-Dependent Manner. Cells. 2018 Nov 30;7(12). pii: E239.
CoA	CoA of AMG PERK 44

Smiles:	CC1=C(C(=C(C=C1)C(=O)C2=C(N(N(C2=O)C3=CC=CC=C3)C)C4=CC=CC=C4)N)C5=CC6=C(C=C5)N=C(C=C6)C.Cl


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