AM4113

CB1 antagonist 2 (AM4113) is an orally active cannabinoid receptor type 1 (CB1R) antagonist. CB1 antagonist 2 suppresses appetite, reduces body weight, and blocks addictive behaviors such as heroin addiction, without causing adverse effects like nausea and depression that are associated with traditional CB1 inverse agonists. CB1 antagonist 2 can be used in studies related to obesity and opioid addiction.


Cat. No.: EX-A17025	Purity: >98%

	Chemical structure of AM4113

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	468	in-stock
250mg	826	in-stock
1g	1660	in-stock

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Synonyms 2	CB1 antagonist 2
CAS No.	614726-85-1
Purity	>98%
Formula	C17H12Cl3N3O
Mol Weight	380.656
Color	White to off-white
State	Solid
Solubility	DMSO : 62.5 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Järbe TU, et al. Intrinsic effects of AM4113, a putative neutral CB1 receptor selective antagonist, on open-field behaviors in rats. Pharmacol Biochem Behav. 2008;91(1):84-90. [2]. He XH, et al. Cannabinoid CB₁ receptor neutral antagonist AM4113 inhibits heroin self-administration without depressive side effects in rats. Acta Pharmacol Sin. 2019;40(3):365-373. [3]. Cluny NL, et al. The neutral cannabinoid CB₁ receptor antagonist AM4113 regulates body weight through changes in energy intake in the rat. Pharmacol Biochem Behav. 2011;97(3):537-543.
CoA	CoA of AM4113

Smiles:	O=C(N)C1=NN(C(C2=CC=C(C=C2)Cl)=C1C)C3=CC=C(C=C3Cl)Cl


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