ALT-007

ALT-007 is an orally active serine palmitoyltransferase (SPT) inhibitor that selectively reduces the levels of toxic very-long-chain deoxysphingolipids to enhance protein homeostasis. ALT-007 restores aging-related loss of muscle mass in a mouse model of sarcopenia. ALT-007 enhances protein homeostasis in both mouse and C. elegans models of aging and disease. ALT-007 can be used for age-related neuromuscular diseases research.


Cat. No.: EX-A12964	Purity: >98%

	Chemical structure of ALT-007

For research only, Do not use for Human!

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CAS No.	2035010-37-6
Purity	>98%
Formula	C25H26F3N5O5
Mol Weight	533.4996
Color	White to off-white
State	Solid
Solubility	DMSO : 25 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Poisson J, et al. Safe and Orally Bioavailable Inhibitor of Serine Palmitoyltransferase Improves Age-Related Sarcopenia. ACS Pharmacol Transl Sci. 2024 Dec 29;8(1):203-215.
CoA	CoA of ALT-007

Smiles:	O=C(NC1C2=C(C=NN2C(C)C)N(C(=O)C3=CN=C(OC)C(OC)=C3)CC1)C=4C=CC=CC4OC(F)(F)F


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