ALK5-IN-8

ALK5-IN-8 is a potent inhibitor of TGFβRI (ALK5). ALK5-IN-8 Inhibits the phosphorylation of ALK5 on its downstream signaling proteins (Smad2 or Smad3) by blocking the binding of TGFβRI to ligands, thereby affecting or blocking TGF-β signaling. ALK5-IN-8 has the potential for the research of various ALK5-mediated related diseases (extracted from patent WO2021190425A1, compound 1).


Cat. No.: EX-A7041	Purity: >98%

	Chemical structure of ALK5-IN-8

For research only, Do not use for Human!

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CAS No.	2705900-81-6
Purity	>98%
Formula	C19H15FN4O2
Mol Weight	350.3464
Color	White to light yellow
State	solid powder
Solubility	Soluble in DMSO 50 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Zhiyong Yu, et al. Transforming growth factor-beta receptor inhibitor. Patent WO2021190425A1.
CoA	CoA of ALK5-IN-8


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