background


Product Information:

ALK-IN-31

ALK-IN-31 (Compound Ld-10) is an orally active ALK inhibitor (IC50: 1135 nM). ALK-IN-31 exhibits excellent antiproliferative activity against lung cancer H2228 cells with an IC50 value of 1.35 μM. ALK-IN-31 induces apoptosis and arrests cell proliferation in the G0/G1 phase by affecting mitochondrial function. ALK-IN-31 exerts its anti-tumor effect by downregulating the expression of p-AKT and p-mTOR in the PI3K-AKT-mTOR signaling pathway downstream of ALK. ALK-IN-31 can be used in the study of non-small cell lung cancer (NSCLC) .

Cat. No.: EX-A15978    Purity: >98%
Chemical
Chemical structure of ALK-IN-31


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
10mgget quoteinquire
25mgget quoteinquire
50mgget quoteinquire
100mgget quoteinquire
500mgget quoteinquire
1gget quote


CAS No.3043840-25-8
Purity>98%
FormulaC30H33N5O2S
Mol Weight527.68
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Wang R, et al. Novel ALK inhibitors containing DAAP fragments: Rational drug design and anti-tumor activity research. Bioorg Chem. 2025 Jun 15;160:108416.

CoACoA of ALK-IN-31
Smiles:O=C1C2=CC=C(C=C2CCC1)NC=3N=C(NC=4C=CC=CC4NC(=O)C5CCCCC5)C6=C(N3)CCSC6

KEYWORDS: buy ALK-IN-31 | ALK-IN-31 supplier | purchase | cost | manufacturer | order | distributor | buy 3043840-25-8 | 3043840-25-8 supplier