AK305

AK305 is a small-molecule ligand for the SH2 domains of STAT5A, STAT5B and STAT6, with a Ki of 0.4 μM for STAT6 and a Ki of 1.0 μM for both STAT5A and STAT5B. AK305 exhibits only very low or no cell growth inhibitory activity in leukemia cells and does not alter STAT protein levels. AK305 serves as the STAT5 ligand for AK-2292 (HY-148813), a STAT5 PROTAC degrader. AK305 can be used in the research of acute myeloid leukemia .


Cat. No.: EX-A17443	Purity: >98%

	Chemical structure of AK305

For research only, Do not use for Human!

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CAS No.	2982853-56-3
Purity	>98%
Formula	C35H40F2N5O7PS2
Mol Weight	775.822

Reference:	[1].Kaneshige A, et al. Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity in Acute Myeloid Leukemia. Journal of medicinal chemistry. 2023 Feb 23;66(4):2717-2743.
CoA	CoA of AK305

Smiles:	C(P(=O)(O)O)(F)(F)C=1C=C2C(SC(C(N[C@H](C(=O)N3[C@H](C(N(CCC(N(C)C)=O)C4=CC=C(C=C4)C5=NC=CS5)=O)CCC3)[C@](C)(C)C)=O)=C2)=CC1


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