Afuresertib

Afuresertib (GSK2110183) is an orally bioavailable, selective, ATP-competitive and potent pan-Akt kinase inhibitor with Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3, respectively.


Cat. No.: EX-A1574	Purity: >98%

	Chemical structure of Afuresertib

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	497	in_stock
500mg	725	in_stock
1g	922	in_stock
5g	2974	in_stock
10g	4841	in_stock

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Synonyms	GSK-2110183
Synonyms 2	GSK-2110183B
CAS No.	1047644-62-1
Purity	>98%
Formula	C18H17Cl2FN4OS
Mol Weight	427.323
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Yamaji M, et al. Novel ATP-competitive Akt inhibitor Afuresertib suppresses the proliferation of malignant pleural mesothelioma cells. Cancer Med. 2017 Nov;6(11):2646-2659. [2]. Dumble M, et al. Discovery of novel AKT inhibitors with enhanced anti-tumor effects in combination with the MEK inhibitor. PLoS One. 2014 Jun 30;9(6):e100880
CoA	CoA of Afuresertib

Smiles:	CN1N=CC(Cl)=C1C1=C(Cl)SC(=C1)C(=O)N[C@H](CN)CC1=CC=CC(F)=C1


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