Afabicin

Afabicin (Debio 1450) is the proagent of Debio1452, specifically targeting staphylococci without significant activity against other Gram-positive or Gram-negative species. Debio1452 is an inhibitor FabI, an enzyme critical to fatty acid biosynthesis in staphylococci.


Cat. No.: EX-A9304	Purity: >98%

	Chemical structure of Afabicin

For research only, Do not use for Human!

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Synonyms	Debio 1450
Synonyms 2	AFN-1720
CAS No.	1518800-35-5
Purity	>98%
Formula	C23H24N3O7P
Mol Weight	485.4263
Color	White to off-white
State	Solid
Solubility	Soluble in H2O
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years, 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Flamm RK, et al. Activity of Debio1452, a FabI inhibitor with potent activity against Staphylococcus aureus and coagulase-negative Staphylococcus spp., including multidrug-resistant strains. Antimicrob Agents Chemother. 2015;59(5):2583-2587.
CoA	CoA of Afabicin

Smiles:	O=P(O)(O)OCN1C2=NC=C(/C=C/C(N(C)CC(OC3=CC=CC=C43)=C4C)=O)C=C2CCC1=O


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